Manosque has existed since before 966, when it is first mentioned historically. Commerce thrived in the town in the 13th century, leading the population to increase to 10,000 inhabitants. It was at this time that the city walls were constructed. The walls have since been completely destroyed, apart from a few remaining gates. The population suffered greatly starting in the 18th century due to plagues in 1720 and 1834. Between 1950 and 1970 the town saw a huge increase in population along with other areas south of the Luberon. A threefold increase in inhabitants occurred.
Manosque is connected by the A51 motorway, regional bus routes and a railway.
The Transagglo service provides urban bus lines for Manosque, and its surroundings at a ticket price of €1. Plans can be found on the DLVA website.