Mbandaka is in Congo Basin.
- Catholic Mission station and Central African history research centre of Bamanya
Church of the Missionaries of the Sacred Heart (MSC) at Bamanya, Equateur province, 2008 A large research centre for Central African history, originally set up by Fathers Gustaaf Hulstaert (1900–1990) and Honoré Vinck, is at the Catholic mission station of Bamanya (Missionaries of the Sacred Heart (MSC)), 10 kilometres east of Mbandaka.
- Botanic Garden of Eala
One of the finest botanical gardens of central Africa is at nearby Eala, about 7 km east of the town centre. The Botanic Garden of Eala, founded in 1900, contains between 4,000 and 5,000 species. It covers approximately 370 hectares with special collections (125 ha), forest (190 ha), marsh (50 ha) and savanna "Euobe" (7 ha). The garden is neglected and unfenced and there is illegal logging. The last catalogue was published in 1924.
- First Habitat for Humanity International housing project
Mbandaka is the home of the world's first project of Habitat for Humanity International. Habitat for Humanity's founder Millard Fuller served as missionary with the Disciples of Christ Church in Mbandaka from 1973-76. The housing project Fuller started in Mbandaka in 1973 became the original project of Habitat for Humanity when Fuller founded Habitat upon his return to the United States.
- University of Mbandaka