The Orontes Valley is a region in west-central Syria.
- 1 Apamea — a former Roman city which once housed about half a million people. Apamea was hit by an earthquake in the 12th century and much of it was destroyed but it still boasts a long street lined with columns, some of which have twisted fluting.
- 2 Kadesh - the site of the Battle of Kadesh between the Hittites and Egyptians in the 13th century BC. It was destroyed by the invading Sea Peoples in around 1178 BC. However, Hellenistic remains have been found in the upper levels of the tell (ruin-mound), and the summit is still occupied today.