- 1 Skopje (Скопје) — the national capital; a truly multicultural city with just about any ethnicity in Balkans present, and almost innumerable sights from Roman, Byzantine, Ottoman, and modern times
- 2 Demir Kapija (Демир Капија) — home to former royal wineries, ancient ruins, and hub for surrounding mountains which offer a wide range of outdoor sports, and last but not the least mighty "Iron Gate" Canyon
- 3 Kavadarci (Кавадарци) — town at the heart of Macedonian wine country
- 4 Negotino (Неготино) — some of the best wine and rakija in the country, the town is easily accessible by Skopje-Greece highway and railway
- 5 Veles (Велес) — town on the valley of Vardar River with a rich cultural heritage and centuries-old churches
- 1 Čaška (Чашка, Chashka) — rural municipality including the Azot historical region, famous for its 6000-year-old Globular Flute
- 2 Stobi (Стоби) — the most famous archaeological site in the country, Stobi has some well-preserved ruins from both pre-Roman (Paeonian and Ancient Macedonian) and Roman periods
Povardarie, forming the central stretch of North Macedonia between Serbian and Greek borders, is a land of mountains, canyons, and valleys, dominated by the River Vardar, the longest river of the country.