Wytheville is a city in Southwest Virginia.

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Wytheville is located at the intersection of two interstate highways. I-77 and I-81 provide access from the neighboring states of North Carolina, Tennessee, and West Virginia. I-81 also connects Wytheville to the larger metro areas of Northern Virginia.

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Routes through Wytheville
CharlestonBluefield  N   S  → Jct   EUnion GroveCharlotte
RoanokeRadford  N   S  BristolKingsport
HuntingtonBluefield  NW   SE  Mount AiryWinston-Salem



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