Hannibal is best known as the boyhood home of author Samuel Longhorn Clemens, more commonly known as Mark Twain. Twain's The Adventures of Tom Sawyer and Adventures of Huckleberry Finn are set in Hannibal. Many historical sites in the city revolve around Twain and his writings, which occupy a prominent place in the history of the Underground Railroad era.
From the south: U.S. Route 69 or U.S. Route 71.
From the west: U.S. route 36
From the east: Interstate 72
From the north: U.S. Routes 61/24
American Airlines partner Cape Air operate flights from St. Louis to nearby (28 miles away) Quincy, Illinois.
- Mark Twain Dinette, 3rd St & Hill St, ☏ .
- The Becky Thatcher Restaurant, 213 N. 3rd Street, ☏ .
- Garth Woodside Mansion (Hannibal Bed And Breakfast), 11069 New London Road, toll-free: . A bed and breakfast and restaurant in a beautiful mansion where Mark Twain himself stayed.
Travelers interested in the creative works of Mark Twain might also head west along U.S. Route 36 to Marceline, childhood home of another creative genius, Walt Disney.
|Routes through Hannibal|
|St. Joseph ← Marceline ← ends ←||W E||→ Junction to Quincy → Jacksonville → Springfield|
|Burlington ← Fort Madison ← Junction W E ←||N S||→ Bowling Green → St. Louis|