city in and county seat of Brule County, South Dakota, United States

Chamberlain is a city in the Great Lakes region of South Dakota. It is along the east bank of the Missouri River.

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Routes through Chamberlain
Rapid CityOacoma  W   E  MitchellSioux Falls
END ← Jct W   E  W   E  → Jct W  YanktonVermillion



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